Click here to learn about some of the organizations helping those affected by the earthquakes.

The two powerful earthquakes may become the most devastating in Venezuela's modern history.

Venezuela sits along the Caribbean plate. It is not part of the infamous Ring of Fire that snakes around the Pacific Ocean, where earthquakes -- especially of higher magnitude -- are relatively common.

An earthquake of this high a magnitude causes so much damage in a place like Venezuela because Venezuela’s infrastructure is not as prepared as countries along the Ring of Fire, like Japan.

The U.S. Geological Survey estimates that the death toll will likely go over 1,000 and potentially could exceed 10,000.

-ABC News’ Kenton Gewecke

The U.S. Southern Command said it is working with the State Department to support a U.S. government relief operation in Venezuela.

“Our joint forces are moving quickly to bring the unmatched airlift, logistics, and lifesaving capabilities of the U.S. military to help save lives and support the Government of Venezuela during this crisis,” a SOUTHCOM statement said.

-ABC News’ Luis Martinez

Simón Bolívar International Airport, Venezuela’s main airport in Caracas, will be closed until at least Friday, according to the Interior Ministry.

-ABC News’ Aicha El Hammar

Secretary of State Rubio said he spoke with Venezuela’s acting president, Delcy Rodriguez, and he said the U.S. is sending search and rescue teams.

“We’re maybe already deploying search and rescue teams from Fairfax County, Virginia, and Los Angeles. There'll be some others we'll add,” Rubio said.

"That’s their most immediate need right now, is search and rescue efforts. They have a bunch of collapsed buildings, and so they'll need a lot of help in terms of digging through that,” he said.

"The airport there is badly damaged, so we'll have to rely on the Department of War to deploy assets there, and then we're also helping them with some overhead imagery, especially in coastal areas where they don't have full visibility over what the damage has been and what the impact has been,” Rubio said.

He said the administration would have "a better assessment" of Venezuela’s longer-term needs “when we're on the ground.”

Rubio declined to put a dollar amount on the aid the U.S. would commit to Venezuela, saying it was too soon.

He said Qatar, El Salvador, Chile and other countries have also offered to help.

-ABC News’ Shannon Kingston