While passing around the far side of the moon, the Orion spacecraft reached its maximum distance from Earth at 252,760 miles.

Shortly after losing communication with NASA, the Artemis II crew is making its closest approach to the moon.

Orion will be about 4,070 miles above the surface of the moon, according to NASA.

The Artemis II astronauts will be the first humans to see most of the far side of the moon, or the side not visible from Earth, since the Apollo missions.

"It turns out there's about 60% of the far side, I think, that has never been seen by human eyes because of the lighting conditions," Reid Wiseman, mission commander, said during a news conference on March 29. "Apollo always wanted that light on the front side of the moon for their landing and launch capability. ... We've seen it in satellite photos, but humans have never, ever seen that before. That's cool."

The Artemis II crew has reached the far side of the moon and has entered a communications blackout, NASA said.

The federal space agency said the communications blackout is planned and should last for about 40 minutes as Orion passes behind the moon.

The moon blocks the radio signals needed for Mission Control to maintain contact with Orion via the Deep Space Network, which is NASA's international array of giant radio antennas that supports interplanetary spacecraft missions.

NASA has said the Artemis II crew will now make its closest approach to the moon at 7:00 p.m. ET and will reach its furthest distance from Earth at 7:02 p.m. ET.

Previously, the crew was supposed to make its closest approach at 7:02 p.m. ET and reach maximum distance from the Earth at 7:07 p.m. ET.

-ABC News' Briana Alvarado

Following the path of Artemis II may be confusing as the astronauts, mission control and others use specific jargon and phrases.

Here are explanations of some of the terminology people may hear over the course of the mission:

Translunar injection burn

The translunar injection burn is the final step that sends the crew on the path to the moon, committing the Orion spacecraft to the remainder of its 10-day mission.

Lasting just minutes, it's a single-engine firing that propels the spacecraft out of Earth's orbit and on a "free-return trajectory."

Universal waste management system

The universal waste management system, otherwise known as a space toilet, is located inside a stall just like in a public restroom on Earth, according to NASA.

Space toilets use air flow to pull urine and feces away and into receptacles, which are stored for disposal. The astronauts have a handlebar to hold themselves down while using the toilet in the absence of gravity.

Read more here about the terms and jargon you may come across during the Artemis II mission.