During Friday's press conference, NASA leaders gave a preview of the Artemis II crew's upcoming lunar flyby.

On Saturday, the crew will take a selfie of the spacecraft and test some thruster flight modes on Orion.

On Monday, during the six-hour lunar observation period when the crew is on the far side of the moon, the astronauts will be at their closest approach to the lunar surface.

They will be making visual observations as well as photographs and video. The observation period will begin at around 2:30 p.m. ET, NASA said.

The blackout period, when the crew is behind the moon and loses communications with Mission Control, is expected to last about 40 minutes.

When asked if there is reason to worry about the astronauts when they are behind the moon and out of contact with Earth, Judd Frieling, Artemis flight director, said, "Physics takes over and physics will absolutely get us back to the front side of the moon."

-ABC News' Matthew Glasser

During a press conference on Friday, NASA leaders said the Artemis II crew is in "great spirits" and "really excited about the opportunity to be there and what's going on."

Orion's navigation and propulsion systems are performing so well that thew crew will not perform the planned trajectory burn scheduled for this evening, NASA said.

"I think it's really good to see that we don't need these minor correction burns. It shows that our navigation performance and our ability to get ranging has been outstanding," Howard Hu, program manager for the Orion spacecraft, said

On Friday, the astronauts spent some time conducting a "noise characterization" assessment of the toilet's noise levels.

The crew also had time to exercise and did a CPR demonstration. NASA said the astronauts are conducting a medical kit evaluation and will test emergency communications with the Deep Space Network.

-ABC News' Matthew Glasser

The Artemis II astronauts woke up around 1:00 p.m. ET on day 3 of their mission to the moon.

"Whenever you want to do some wake-up music, we can do some post-wake-up music," mission commander Reid Wiseman told Mission Control.

NASA's Mission Control in Houston played "In a Daydream" by the Freddy Jones Band.

Day 3 will include demonstrating CPR procedures in space and checking out some of Orion's medical kit, including the thermometer, blood pressure monitor, stethoscope and otoscope, according to NASA.

The crew will also begin to configure the cabin for its upcoming lunar flyby so it has the most ideal setup for capturing images and data of the far side of the moon.

Additionally, the Artemis II astronauts will be doing a Deep Space Network emergency communications test make sure the system works.

-ABC News' Matthew Glasser and Mary Kekatos

NASA released the first batch of high quality photos of Earth taken from the Orion capsule.

The images show the crew’s view as they look back at the pale blue dot we call home, while continuing their journey toward the moon.

According to NASA, the images were taken on Artemis II commander Reid Wiseman's "personal computing device, PC or tablet."

-ABC News' Briana Alvarado

Despite all the preparation, safety systems and redundancies, the nature of human spaceflight is inherently risky, according to experts.

"I think it'd make everybody feel comfortable to say that all the risk was knocked down to zero," Danny Olivas, former NASA astronaut and engineer, told ABC News. "The truth is it is not and never will be."

NASA is using a variety of tools and systems to ensure crew safety from launch to splashdown, including customized lifesaving spacesuits, a launch abort system, radiation monitoring, an emergency egress system and other contingencies.

Read more here.

-ABC News' Briana Alvarado