The translunar injection burn has been completed successfully. The Artemis II crew is on its way to the moon.

The crew received two caution indicators on their screen but determined it required no action and proceeded with the burn.

The burn occurred on time at the one day, one hour and 14-minute mark for the mission, according to Mission Control.

NASA Administrator Jared Isaacman was in Mission Control during the TLI burn.

The translunar injection burn is underway. The Orion spacecraft is now committed to its journey to the moon.

Mission Control in Houston has given the final “go” for the translunar injection burn. The Artemis II crew said they are a “go” for the burn.

Mission Control told the astronauts, “When the engine ignites, you embark on humanity’s lunar homecoming arc and set the course to return Integrity and her crew safely home. Houston is go for TLS.”

Astronaut Christina Koch replied, “Crew is go for TLI. With this burn to the moon, we do not leave Earth, we choose it."

-ABC News' Matthew Glasser

Following the path of Artemis II may be confusing as the astronauts, mission control and others use specific jargon and phrases.

Here are explanations of some of the terminology people may hear over the course of the mission:

Translunar injection burn

The translunar injection burn is the final step that sends the crew on the path to the moon, committing the Orion spacecraft to the remainder of its 10-day mission.

Lasting just minutes, it's a single-engine firing that propels the spacecraft out of Earth's orbit and on a "free-return trajectory."

Universal waste management system

The universal waste management system, otherwise known as a space toilet, is located inside a stall just like in a public restroom on Earth, according to NASA.

Space toilets use air flow to pull urine and feces away and into receptacles, which are stored for disposal. The astronauts have a handlebar to hold themselves down while using the toilet in the absence of gravity.

Read more here about the terms and jargon you may come across during the Artemis II mission.

Despite all the preparation, safety systems and redundancies, the nature of human spaceflight is inherently risky, according to experts.

"I think it'd make everybody feel comfortable to say that all the risk was knocked down to zero," Danny Olivas, former NASA astronaut and engineer, told ABC News. "The truth is it is not and never will be."

NASA is using a variety of tools and systems to ensure crew safety from launch to splashdown, including customized lifesaving spacesuits, a launch abort system, radiation monitoring, an emergency egress system and other contingencies.

Read more here.

-ABC News' Briana Alvarado