During a press conference on Thursday night, Lori Glaze, acting associate administrator at NASA, said that the critical translunar injection burn was "flawless."

“From this point forward, the laws of orbital mechanics are going to carry our crew to the moon, around the far side and back to Earth,” Glaze said.

Astronaut Jeremy Hansen told Mission Control that the crew is "glued to the window" of the spacecraft, enjoying the views of Earth.

“None of us can get to lunch because we’re glued to the window. We’re taking pictures,” he said, calling the sight of their home planet from space "phenomenal."

Speaking to Mission Control after the successful translunar injection burn, Canadian Space Agency astronaut Jeremy Hansen shared a message of gratitude, saying, "We firmly felt the power of your perseverance during every second of that burn."

"With that successful TLI, crew’s feeling pretty good up here on our way to the moon, and we just wanted to communicate to everyone around the planet who’s worked to make Artemis possible that we firmly felt the power of your perseverance during every second of that burn."

"Humanity has once again shown what we are capable of, and it’s your hopes for the future that carry us now on this journey around the moon," he added.

The translunar injection burn has been completed successfully. The Artemis II crew is on its way to the moon.

The crew received two caution indicators on their screen but determined it required no action and proceeded with the burn.

The burn occurred on time at the one day, one hour and 14-minute mark for the mission, according to Mission Control.

NASA Administrator Jared Isaacman was in Mission Control during the TLI burn.

The Orion crew module will be falling to Earth at over 24,000 mph when it encounters the atmosphere. As the atmosphere thickens, friction will slow the spacecraft. It will also create a lot of heat -- up to 5,000 degrees Fahrenheit, which is more than twice as hot as lava from a volcano -- turning Orion into a fireball.

Orion's heat shield, located on the underside of the spacecraft, will protect the spacecraft and its crew from the intense temperatures of reentry. Onboard maneuvering jets ensure Orion maintains the orientation required to keep the heat shield pointed toward Earth during reentry.

"Importantly, there's this coating on the outside that's meant to melt upon being heated rather than absorbing that energy," ABC News contributor and astrophysicist Hakeem Oluseyi said. "So, it's much in the same way that a car is meant to crumple in an accident rather than being a stiff object. You want to dissipate that energy. You need the energy to go somewhere that is not inside the capsule."