Epidemiological research on environmental factors and cancer risk is plagued by methodological pitfalls, such as subjects' bias in recalling previous exposures and insufficient follow-up time for a disease that can develop slowly, like cancer. A study examining cellphone use in the decade leading up to a cancer diagnosis, for example, might be unable to detect a connection if the disease were triggered 15 years ago.

\"The only thing one could say is that maybe we need studies with a much longer follow-up period,\" Duke's Friedman said.

Nevertheless, some experts believe the evidence, inconclusive as it is, warrants caution. ABC News reached out to 92 physicians, 65 of whom said they would continue to hold their cellphones up to their ear, but 27 said they will use hands-free devices to minimize their risk.

In light of the IARC decision, the World Health Organization and national health agencies, such as the U.S. Centers for Disease Control and Prevention, might decide to provide similar guidance on cellphone use.

\"[The] IARC is saying that we should be cautious and think through what we do when we regulate exposures from cellphones,\" Georgetown's Shields said. \"They follow the precautionary principle and want to maximally protect public health.\"

The Federal Communications Commission (FCC) requires cell phones to meet safety standards based on the advice of federal health and safety agencies, an agency spokesman said in a statement.

\"We support the IARC recommendation for more research to clearly identify any potential health risks and, as appropriate, consider whether further actions may be required.\"

The Associated Press contributed to this report.

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