The biopic, from director Chinonye Chukwu, follows the story of Mamie Till-Mobley, who fought for justice after her 14-year-old son was lynched in Mississippi in 1955 following false accusations from a white woman.
"The lynching of my son has shown me that what happens to any of us, anywhere in the world, had better be the business of us all," Mamie, played by Danielle Deadwyler, says in the trailer.
The film also stars Jalyn Hall as Emmett and Whoopi Goldberg as Emmett's grandmother, Alma Carthan.
"Till" will make its world premiere at the 60th New York Film Festival, which takes place from Sept. 30 to Oct. 16. It premieres in select theaters on Oct. 14 and opens everywhere on Oct. 28.
An ABC Audio podcast also chronicled the life of Mamie Till-Mobley in "Reclaimed: The Story of Mamie Till-Mobley." It is out now.