It's been about 17 years since Britney Spears and Madonna teamed up for "Me Against the Music" from Spears' 2003 album "In the Zone" and, now, it seems they may be cooking up a brand new collaboration.

The "Toxic" singer sent fans into a frenzy on Tuesday when she uploaded a photo that read "Rebel Heart" in pink lettering against a marble-like surface, which immediately sparked a connection to Madonna's 2015 album of the same name.

It also didn't help that Spears further teased with three "speak no evil" monkey emojis in the caption, hinting that her lips are sealed on the matter.

It should be noted, however, that "You Say" singer Lauren Daigle also has a 2018 song called "Rebel Heart."

Either way, Spears' followers are starved for new music. The 38-year-old hasn't released anything since her "Glory" era in 2016 with the singles "Make Me..." and "Slumber Party."

As for Madonna, she has yet to go on a musical hiatus. "Rebel Heart" dropped in 2015 and spawned the dance hits "B**** I'm Madonna" -- featuring vocals from Nicki Minaj -- and "Ghosttown."

The 61-year-old's most recent album is "Madame X," which she released in 2019.