Alongside the clip of the pair moving to the tune "Dance Me to the End of Love" by Leonard Cohen, she wrote, "Celebrating with the king @anthonyhopkins 👑 his 2nd Oscar for his extraordinary performance in 'The Father.'"
Hopkins appeared to appreciate the shout-out, commenting, "Thank you queen 👸🏻 for the love and laughter. A memorable, beautiful day."
Many took to Twitter to voice their surprise at the clip, unaware that the two knew each other. However, Hopkins and Hayek's friendship appears to go back many years, as Hayek attended Hopkins' Hollywood Walk of Fame ceremony in 2003.
The Welsh actor's win at the 2021 Oscars was somewhat of a shock to many, as most expected late actor Chadwick Boseman, who died in August after battling colon cancer, to win the award his role in "Ma Rainey's Black Bottom."
While Hopkins was not present at the award show, he shared a video from Wales the next day to express his gratitude for the Oscar win.
"At 83 years of age I did not expect to get this award," he said. "I really didn’t." He also took a moment to pay tribute to Boseman in the video.
"I want to pay tribute to Chadwick Boseman who was taken from us far too early," he said.
See his full acceptance speech here.