The Patriots and Spikes mutually agreed to the IR designation as opposed to an outright release, which would have made the linebacker available to the remaining playoff teams.
The Patriots host Andrew Luck and the Indianapolis Colts in Saturday night's AFC divisional playoff game.
Spikes, who will be a free agent this offseason, will receive the Patriots' playoff shares this postseason before hitting the open market on March 11.
Spikes, 26, recorded 86 tackles -- the third-highest total on the team -- and one interception this season, his fourth with the Patriots.
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