The National Hurricane Center said a "life-threatening storm surge and devastating winds" were likely to occur along Florida's Panhandle and Alabama's coasts, in an hourly update for 1 p.m. ET.

Evacuation orders have been issued for several counties in the Florida Panhandle and Alabama as Hurricane Isaias, now a powerful Category 3 storm, inches closer to landfall.

Mobile Regional Airport said in a social media post that no commercial flights will operate after 1 p.m. ET Friday.

Additionally, all flights are cancelled Friday at Dothan Regional Airport in Alabama, the Dothan Airport said.

The FAA said that Hurricane Isaias could cause Gulf route closures.

Hertz is also waiving early and late return fees, reservation change fees and one-way rental fees for travelers impacted by the event.

Escambia County Public Safety Director Eric Gilmore warned residents of the Northwest Florida county, which includes Pensacola, that time is running out to prepare for Hurricane Isaias.

"Your time for prep is coming to an end very fast," Gilmore said during a press conference Friday morning. "Make sure by this afternoon, by noon today, you're in your safe space."