My thoughts & prayers are w Vice President Biden @VP, Dr. Jill Biden @DrBiden & the entire Biden family on the tragic passing of Beau Biden

— Chelsea Clinton (@ChelseaClinton) May 31, 2015

Beau Biden was a throughly admirable man. Great husband, father, son, veteran and public servant. My heart aches for the Biden family.

— David Axelrod (@davidaxelrod) May 31, 2015

So crushed to hear of the loss of Beau Biden. What a great man. Iraq vet, AG, father and son. Example of American hero.

— Jim Messina (@Messina2012) May 31, 2015

Saddened by the news of Beau Biden's passing. My prayers are with The Vice President, Dr. Biden and the whole family.

— Jeb Bush (@JebBush) May 31, 2015

From the entire Cheney family - our deepest sympathy and heartfelt prayers to the @VP Biden family.

— Liz Cheney (@Liz_Cheney) May 31, 2015

Senate Minority Leader Harry Reid, who served along side the vice president during his time in the Senate, called Beau Biden a \"wonderful, strong and courageous man.\"

\"His life was so rich and it is unspeakably sad to see him leave us far too soon. Beau's dedication to public service was deep, broad and profound. He embodied the best and most noble traits that his parents sought to instill in him,\" Reid said in a statement. \"I know Joe is very proud and he should be proud because Beau was simply a joy to know.\"

Ron Klain, former chief of staff to the vice president, said the passing of Beau Biden, who was considering a run for governor in Delaware, was a loss for the country.

Sen. Chris Coons, D-Delaware, said Beau Biden's death a \"great less for his family and friends and for Delaware.\"

\"Throughout his life, Beau never shied away from doing the right thing, even when it meant doing the hard thing. Beau served his country and community with honor, and that's how he will be remembered,\" Coons said. \"My family knew Beau as a family man devoted to his wife, Hallie, and their children, Natalie and Hunter, and as a hardworking, kind-hearted person.\"

Beau Biden served in the Delaware National Guard starting in 2003 and participated in Operation Enduring Freedom in Iraq as part of a year-long deployment in September 2009.

It is with great sorrow and heavy hearts that we share the news of the loss of a great leader, Maj. Beau Biden. http://t.co/E77RPIHlbQ

— Del National Guard (@DelawareNG) May 31, 2015

ABC News' Erin Dooley contributed to this report.

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