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Following her event in Boston, Massachusetts on Thursday, Democratic candidate Hillary Clinton expressed disbelief.

\"It is just beyond my comprehension that we are seeing these mass murders happen again and again and again,\" Clinton told the press. \"And as I have said, we have got to get the political will to do everything we can to keep people safe. You know, I know there is a way to have sensible gun control measures that help prevent violence, prevent guns from getting into the wrong hands and save lives. And I am committed to doing everything I can to achieve that.\"

Another devastating shooting. We need sensible gun control measures to save lives, and I will do everything I can to achieve that. -H

— Hillary Clinton (@HillaryClinton) October 1, 2015

Donald Trump told the Washington Post, the shooting was \"absolutely a terrible tragedy.\"

\"It sounds like another mental health problem. So many of these people, they're coming out of the woodwork,\" Trump said, the Washington Post reported. \"We have to really get to the bottom of it. It's so hard to even talk about these things, because you see them and it's such a tragedy.\"

The former Governor of Maryland Martin O'Malley, the first Democratic candidate to respond, also offered his thoughts.

My heart is with those who lost so much today in Oregon. -O’M

— Martin O'Malley (@MartinOMalley) October 1, 2015

Tweets won't stop this. Thoughts and prayers won't, either. Only real gun reforms will stop mass shootings from occurring nearly every day.

— Martin O'Malley (@MartinOMalley) October 1, 2015

My thoughts and prayers are with the victims and their families of this terrible tragedy at Umpqua Community College.

— Lindsey Graham (@LindseyGrahamSC) October 1, 2015

Another senseless tragedy with more innocent people killed. Our hearts go out to the families. -B

— Bernie Sanders (@SenSanders) October 1, 2015

The thoughts and prayers of Ohioans go out to the families & victims of the tragic shooting in Oregon today. -John

— John Kasich (@JohnKasich) October 1, 2015

It's with a heavy heart that we all pray for those killed or injured in Oregon today. #UCCShooting

— George E. Pataki (@GovernorPataki) October 1, 2015

My prayers are with everyone in Oregon. May the peace of God, which transcends all understanding, guard your hearts.

— Gov. Mike Huckabee (@GovMikeHuckabee) October 1, 2015

During a radio interview today with Hugh Hewitt, Republican candidate Dr. Ben Carson said that the aftermath of the shootings would lead to more calls for gun control.

“Obviously there are going to be those calling for gun control but that happens every time we have one of these incidents. Obviously that’s not the issue,\" Carson said. \"The issue is the mentality of these people. And we need to be looking at the mentality of these individuals and seeing if there are any early warning clues that we can gather that will help us as a society be able to identify these people ahead of time.

“What I worry about is when we get to the point and we say we have to have every gun registered, we have to know where the people are, and where their guns are,\" he added. \"That is very dangerous that I wouldn’t agree with at all.”

ABC News' Lissette Rodriguez contributed to this report.

Get real-time updates as this story unfolds. To start, just \"star\" this story in ABC News' phone app. Download ABC News for iPhone here or ABC News for Android here.

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