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  • The fire broke out around 7 p.m. Eastern Time at a five-story apartment building in the Bronx.
  • It was sparked by a 3-year-old boy playing with a stove on the first floor.
  • The boy's mother fled with her children, and left the door open to the burning apartment.
  • The open door allowed the flames to quickly spread up the stairwell to the rest of the building.
  • At least 12 people killed, including seven adults and five children.
  • It's the largest loss of life from a fire in New York City, other than the Sept. 11, 2001, terror attack, in more than a quarter century.

    • \"PHOTO:
    FDNY
    PHOTO: At least 15 people were seriously injured in a massive fire in the Belmont section of Bronx, New York, according to the FDNY.
    >

    'This loss is unprecedented'

    The blaze broke out in the brick building on Prospect Avenue in the Bronx's Belmont neighborhood at around 7 p.m. Eastern Time, forcing residents fleeing the flames out into the bitter cold, many without coats.

    Seven adults and five children died from the fire, including five who weren't able to evacuate the burning building. Another four people who were critically injured in the blaze and hospitalized \"are seriously fighting for their lives,\" the fire commissioner said.

    \"Last night’s tragic fire, other than 9/11, was the worst loss of life from a fire in our city in almost 28 years,\" Nigro told reporters. \"This loss is unprecedented.\"

    At the moment, he said, there doesn't appear to be anything problematic about the fire safety in the building.

    \"PHOTO:
    Wang Ying/Xinhua
    PHOTO: Emergency workers remove a body from the site of an apartment fire in the Bronx, New York, Dec. 29, 2017.
    >

    'We may lose others as well'

    Firefighters arrived on the scene within minutes, with more than 160 of them braving the frigid temperatures to battle the flames, quelling them completely by about 10 p.m. Eastern Time, according to the city fire department..

    The instability of the charred building prevented firefighters on Thursday night from conducting a full sweep of the building for more fatalities.

    \"The search of the building continues so we know that, even though it's horrible to report 12 are dead already, we may lose others as well,\" New York City Mayor Bill de Blasio said at a press conference Thursday night.

    \"PHOTO:
    FDNY
    PHOTO: At least 15 people were seriously injured in a massive fire in the Belmont section of Bronx, New York, according to the FDNY.
    >

    At least one person on every floor of the building was killed, according to city officials. Five people were pronounced dead on the scene, and seven later died in area hospitals.

    \"I came out through the window. Yeah, there was smoke everywhere. I couldn't see the door. The door was ... I couldn't see the door. Was covered in smoke already,\" Matthew Igbinetion, a resident of the building, told WABC.

    \"PHOTO:
    Andres Kudacki/AP
    PHOTO: Emelia Ascheampong, right, a resident of the building where at least 12 people died in a fire, is embraced by a friend, Dec. 29, 2017, in the Bronx borough of New York. Ascheampong, her husband and four children, survived by using a fire escape.
    >

    Young children among the dead

    Among the children who died from the fire were three young girls ages 1, 2 and 7 as well as a boy whose age has yet to be released, according to the New York City Police Department.

    \"They were burned, even little kids on the stretchers, burned,\" a resident of the building told ABC station WABC in New York City.

    \"Firefighters
    AP
    Firefighters respond to a deadly fire Thursday, Dec. 28, 2017, in the Bronx borough of New York.
    >

    The seven adults killed include three women ages 19, 37 and 63.

    One family is still looking for a missing son, according to WABC.

    The fire is the city's deadliest, excluding the Sept. 11 attacks, since the fire at the Happy Land nightclub in the Bronx in March 1990, which killed 87 people.

    ABC News' Eva Pilgrim contributed to this report.

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