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Heartsick for Ruthie and her family. https://t.co/T7Ox6y4BeH

— Lin-Manuel Miranda (@Lin_Manuel) March 6, 2018

The preliminary investigation indicated that the 44-year-old woman driving the Volvo \"failed to maintain control of the vehicle\" as she headed west on Ninth Street and hit the pedestrians at Fifth Avenue in a busy commercial area, police said in a statement.

New York City Mayor Bill de Blasio, who owns a home in the neighborhood, said that six people were taken to a local hospital, including the children who died.

“It’s really, really sad what happened today,” de Blasio said.

\"PHOTO:
Leah Finnegan/Twitter
PHOTO: Two children are dead and a woman, believed to be their mother, was hospitalized Monday after being struck by a car today in New York City, authorities said.
>

“This loss of life is tragic and painful for all of us, particularly those of us who are parents,” he added.

De Blasio was confronted Tuesday morning by protesters demanding safer streets as he arrived to work out at a YMCA, less than a block from where the fatal incident occurred.

Police said the two children and their mothers, ages 33 and 34, were transported to nearby Methodist Hospital. A fifth victim, a 46-year-old woman, was also taken to the hospital by paramedics, police said. The injured victims were in stable condition.

The driver of the car, who was not immediately identified, was taken to NYU Langone Hospital in Brooklyn, where she was also in stable condition.

\"Ruthie is beloved by her many friends and colleagues in the Broadway and touring communities. She is always kind and always has a smile. It is our honor to help her in this difficult time,\" Jack Stephens -- who was the company manager on \"The King and I\" -- wrote on the GoFundMe page he established for Miles.

On the GoFundMe site for Lew's family, friends wrote, \"While there is nothing we can do or say to bring their boy back, we hope these funds will serve as an expression of the community supporting them during this time.\"

ABC News' Meghan Keneally contributed to this report.

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