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Kimmel's son was born with a heart defect and has already undergone two open-heart surgeries, including one three days after his April 21 birth. The late-night host opened up to his viewers about his son's condition during an emotional 13-minute monologue that drew an outpouring of support.

Watch & prepare to tear up. Thanks @jimmykimmel for sharing your story & reminding us what's at stake w/health care.https://t.co/2kTEeUEG2f

— Hillary Clinton (@HillaryClinton) May 2, 2017

Kimmel told Winfrey that he has no regrets about getting personal during his monologue.

\"PHOTO:
Randy Holmes/ABC via Getty Images
PHOTO: Jimmy Kimmel on "Jimmy Kimmel Live", Sept. 14, 2017.
>

\"I don’t know if it was scary, but it was uncomfortable, and it’s not something I looked forward to. I definitely felt a sense of relief when it was over,\" he said. \"And according to polls I’ve seen, it has cost me commercially. That’s not ideal, but I wouldn’t change anything I said.\"

Nor does Kimmel regret speaking out about the nation's health care or gun control.

\"I know my job is, for the most part, to entertain people and make them laugh,\" he said. \"That said, if I can be selfish every once in a while and talk about something serious, that’s important to me, then I do want to take that opportunity. But I don’t want to abuse my position. I pick my battles. Ninety percent of the time, I’ll joke around, but some of the jokes, I hope, make people think.\"

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