British Prime Minister Theresa May tweeted: \"His legacy will not be forgotten.\"
NASA tweeted: \"May you keep flying like superman in microgravity.\"
In 2007, Hawking became the first quadriplegic to experience weightlessness and has said his \"ultimate ambition\" was to go to space aboard a commercial suborbital spaceflight. Richard Branson's company Virgin Galactic once even promised Hawking a trip to space, and Hawking said he accepted immediately.
Fellow scientists also paid tribute to the star of his generation, including U.S. astrophysicist Neil deGrasse Tyson and artificial intelligence researcher Demis Hassabis.
Even the Pontifical Academy of Sciences paid its respects, tweeting a picture of Hawking and Pope Francis.
Google CEO Sundar Pichai weighed in, too.
And world leaders, including Indian Prime Minister Narendra Modi, took to Twitter to celebrate Hawking.
Film director Errol Morris, who directed a documentary on the physicist, wrote: \"We were lucky to have him for so long.\"
Stars who paid tribute to Hawking on Twitter include Steven Tyler, Sharon Stone and Katy Perry.
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