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Director and screenwriter Ava DuVernay thanked the icon for her tremendous impact.

Thank you, Penny Marshall. For the trails you blazed. The laughs you gave. The hearts you warmed. pic.twitter.com/7qPKJa6ApH

— Ava DuVernay (@ava) December 18, 2018

Actor Rob Reiner, who was married to Marshall from 1971 to 1981, said she was \"born with a funnybone and the instinct of how to use it,\" in a tweet.

I loved Penny. I grew up with her. She was born with a great gift. She was born with a funnybone and the instinct of how to use it. I was very lucky to have lived with her and her funnybone. I will miss her.

— Rob Reiner (@robreiner) December 18, 2018

Rosie O'Donnell, who starred in Marshall's 1992 film \"A League of Their Own,\" expressed her devastation on Twitter. She attached a commercial the two starred in together in 1996.

1996 Kmart TV Commercial with Penny Marshall and Rosie O'Donnell https://t.co/XHOgyrCBhs via @YouTube - simply heartbroken #ripPENNY

— ROSIE (@Rosie) December 18, 2018

Acclaimed director Ron Howard said Marshall, \"made the transition from sitcom star to A List movie director with ease & had a major impact on both mediums,\" in a statement on Twitter.

#RIPPennyMarshall She was funny & so smart. She made the transition from sitcom star to A List movie director with ease & had a major impact on both mediums. All that & always relaxed, funny & totally unpretentious. I was lucky to have known & worked with her. https://t.co/pf2kfIkCH4

— Ron Howard (@RealRonHoward) December 18, 2018

\"Big Bang Theory\" star Mayim Bialik said she grew up wanting to be like Marshall.

I grew up wanting to be as funny as Penny Marshall, and had the pleasure of meeting her a few times. Watch some old Laverne and Shirley to see why her brother Garry insisted on casting her. Comedy gold, she was. ?? pic.twitter.com/DhP10j7m8s

— Mayim Bialik (@missmayim) December 18, 2018

Mark Walberg shared a tribute to Marshall on Twitter.

Rest in peace, Penny. Such a wonderful, funny and talented lady. Without her support and encouragement, I would not be where I am today. She will be missed. ?? #PennyMarshall pic.twitter.com/F9ksywXYuG

— Mark Wahlberg (@markwahlberg) December 18, 2018

Danny DeVito said she had a \"heart of gold.\"

Penny Marshall was a sweet woman. I was very fortunate to spend time with her. So many laughs. She had a heart of gold. Tough as nails. She could play round ball with the best of them. Always All love, D

— Danny DeVito (@DannyDeVito) December 18, 2018

William Shatner said Marshall was a \"true treasure.\"

Condolences to the family of Penny Marshall. She was a true treasure! ?? pic.twitter.com/BtM46dAnYq

— William Shatner (@WilliamShatner) December 18, 2018

\"Star Trek\" actor George Takei said she \"truly broke new ground as a director.\"

Penny Marshall brought us great laughter and truly broke new ground as a director. Neither a schlemiel, nor ever a schlimazel, she shall be missed by her many fans. Rest in peace.

— George Takei (@GeorgeTakei) December 18, 2018

Acclaimed actor James Woods called Marshall a \"remarkable talent.\"

I am absolutely devastated. #PennyMarshall was one of my dearest friends. I loved her. Funny, warm, a true individual and remarkable talent. #RidingInCarsWithBoys

— James Woods (@RealJamesWoods) December 18, 2018

Many noted characters from her lengthy list of guest spots on television shows throughout her career.

Fun fact: Penny Marshall was the first-ever celebrity guest star on The Simpsons. She played a sinister babysitter in what was supposed to be the show’s pilot, but it came back with animation issues and instead became the first season finale.

RIP to a true talent. pic.twitter.com/R77oDpq5g2

— Andy Herren (@AndyHerren) December 18, 2018

Barbara Eden, the star of '60s sitcom \"I Dream of Jeannie,\" expressed her condolences on the platform.

I just heard of Penny Marshall's passing. I was such and admirer of hers, such talent she had. My deepest condolences to her family, friends and fans. She and her wonderful brother are reunited. -Barbara

— Barbara Eden (@Barbara_Eden) December 18, 2018

Actress Olivia Munn commended her incredible directorial accomplishments.

Penny Marshall was one of the most important trailblazers. Her comedic talents brought success & fame, but she truly broke the mold w her directing- Big, Awakenings, A League of Their Own- becoming the first woman to direct a movie that grossed $100+ mil. ?? Rest in love, PM ????

— Olivia Munn (@oliviamunn) December 18, 2018

Actress and director Regina King thanked Marshall \"for blazing trails.\"

This one really hit me hard. One of the best to ever do it. From the Boogie Down but always repped LA too #clipperlover Thank you Penny for blazing trails and sharing your talents. You… https://t.co/Pf7H5PrJwH

— Regina King (@ReginaKing) December 18, 2018

Actor Josh Gad acknowledged the strides she made for women in film.

At a time when men dominated, #pennymarshall broke barriers as a director, giving us hit after hit. A League of their Own, Awakenings, & Big aren’t simply great movies. They r classics made by a director who was simultaneously setting up shots while breaking down walls. RIP

— Josh Gad (@joshgad) December 18, 2018

Larry King paid tribute to Marshall in a statement on Twitter.

So saddened by Penny Marshall's passing. Her work entertained us for years — what a remarkable woman! One thing I'll always remember about Penny — & maybe some people don't know this — she had one of the best sports memorabilia collections I've ever seen. RIP, Penny Marshall.

— Larry King (@kingsthings) December 18, 2018

Filmmaker Kevin Smith wrote about her influence as well.

Farewell to the lady I imitated as a kid before becoming her neighbor years later, legendary sitcom star and BIG director Penny Marshall. I got to tell Penny that LEAGUE OF THEIR OWN is one of my favorite films when we recorded 4 epic podasts at my house: https://t.co/h7HU9poX7D https://t.co/B7qorn7ZAj

— KevinSmith (@ThatKevinSmith) December 18, 2018
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