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In his resignation letter, provided to ABC News, Gottlieb says he will stay on in his job for another month but he does not cite a reason for his leaving.

\"I’m fortunate for the opportunity that the President of the United States afforded me to lead this outstanding team, at this time, in this period of wonderful scientific advances. I’m deeply grateful for your support and the support of the President and his team in advancing many critical public health goals,\" he wrote.

I’m immensely grateful for the opportunity to help lead this wonderful agency, for the support of my colleagues, for the public health goals we advanced together, and the strong support of @SecAzar and @realDonaldTrump - This has been a wonderful journey and parting is very hard. https://t.co/1Zu9y7NTwR

— Scott Gottlieb, M.D. (@SGottliebFDA) March 5, 2019

Gottlieb has presided over a number of FDA initiatives including faster approvals for generic drugs and cracking down on unproven procedures like thermography. He also worked to ensure food inspections and other essential services continued during the government shutdown.

One of his signature issues was confronting e-cigarette companies that targeted teens and retailers that sold tobacco to minors.

News of his resignation comes a day after he announced new measures aimed at stores including Walgreens, 7-Eleven and Exxon. In a public rebuke on Monday, Gottlieb highlighted hundreds of incidents where some of the country’s top convenience store chains were found to have sold tobacco products to minors.

The agency has issued warning letters to retailers and e-cigarette manufacturers, requiring them to detail plans for correcting violations.

He said in his letter that he expects FDA to continue those initiatives.

President Donald Trump thanked Gottlieb in a tweet, saying he did an \"absolutely terrific job\" at FDA.

Scott Gottlieb, who has done an absolutely terrific job as Commissioner of the FDA, plans to leave government service sometime next month....

— Donald J. Trump (@realDonaldTrump) March 5, 2019

ABC News' Quinn Owen contributed to this story.

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