Now 79, Fauci has helped lead the nation against HIV-AIDS and other crises over decades but none has tested his political skills like this one -- under Trump.

Tune into ABC at 1 p.m. ET and ABC News Live at 4 p.m. ET every weekday for special coverage of the novel coronavirus with the full ABC News team, including the latest news, context and analysis.

Increasingly, the science guiding Fauci has led him to directly and publicly counter with the president — a leader who has fired or forced out dozens of administration officials who have contradicted him or seemed to steal his spotlight.

The tensions have been evident -- as much has he's tried to deal with them diplomatically. Now, he's explained their differences in some of his most candid terms yet.

\"PHOTO:
The Washington Post via Getty Images, FILE
PHOTO: Dr. Anthony Fauci, right, listens as President Donald J. Trump speaks with the coronavirus task force during a news conference at the White House, March 20, 2020 in Washington.
>

Though Fauci said he doesn't disagree in \"substance\" with language used during the coronavirus task force briefings, “it is expressed in a way that I would not express it, because it could lead to some misunderstanding about what the facts are about a given subject,” Fauci told Science Magazine in an interview.

Fauci addressed the widening gap between his research-based views and the president’s unsubstantiated optimism.

In recent days, they’ve most publicly disagreed on a medication that Trump said he hopes — without evidence, as Fauci has clarified — will treat coronavirus.

On Thursday, Trump declared an anti-malaria drug could be a “game changer” in the effort to develop a coronavirus treatment and announced the drug had been “approved.” The drug, called chloroquine, or hydroxychloroquine, indeed has been approved -- since 1944 -- but to treat and prevent malaria. No drug has been approved to treat COVID-19, and a vaccine is estimated to remain at least a year away.

When asked if the drug was promising Friday, Fauci, standing next to Trump, said “the answer is no” because “the evidence you’re talking about … is anecdotal evidence.”

Fauci was also seen raising his hand to his temple as the president told reporters that Secretary of State Mike Pompeo would be leaving the briefing early to return to the “the State Department, or as they call it the Deep State Department.”

Asked if he’d been criticized later for the gesture, which was caught on television and widely circulated in internet memes as evidence of Fauci’s disagreement with the president, Fauci told Science, “No comment.\"

Dr. Fauci's reaction when Pres. Trump calls the State Department \"the Deep State Department.\" pic.twitter.com/woZ10XsccI

— Evan McMurry (@evanmcmurry) March 20, 2020
\"PHOTO:
Brendan Smialowski/AFP/Getty Images
PHOTO: Dr. Anthony Fauci speaks as President Donald Trump listens during the daily press briefing on the Coronavirus pandemic situation at the White House, March 17, 2020.
>

In another instance, the president suggested that China's government could have shared details about a new coronavirus epidemic months earlier than it did. Fauci has publicly knocked that assertion down, which he said “doesn’t comport” with the facts, and explained the behind-the-scenes efforts to tamp down that narrative.

He told the \"appropriate people,\" he said, who passed along the message. He explained his means — and limits — in correcting the president.

“The next time they sit down with him and talk about what he’s going to say, they will say, ‘By the way, Mr. President, be careful about this and don’t say that.’,” Fauci said. “But I can’t jump in front of the microphone and push him down. OK, he said it. Let’s try and get it corrected for the next time,” Fauci told Science.

Given the volatility of Trump’s administration, which has an 82% turnover rate among senior advisers, according to research by the nonprofit public policy organization the Brookings Institution, Fauci’s outspokenness raises concerns about his future. When he’s missing from a coronavirus task force briefing, questions about his whereabouts immediately flood Twitter.

“How are you managing to not get fired?” Science pointedly asked Fauci in the interview published Monday.

“Well, that’s pretty interesting because to [Trump’s] credit, even though we disagree on some things, he listens. He goes his own way. He has his own style. But on substantive issues, he does listen to what I say,” Fauci said.

Standing next to the president on Saturday, Fauci sought to reconcile his role with what he sees as the president's.

“The president is talking about hope for people.  And it’s not an unreasonable thing: to hope for people,” Fauci said, acknowledging the differences between what he and the president said. “And then you have the other group — which is my job, as a scientist, to say my job is to ultimately prove, without a doubt, that a drug is not only safe, but that it actually works.”

“You really got to have a balance,\" he said. \"I’ve got to do my job as a scientist and others have other things to do.\"

What to know about coronavirus:

ABC News' Jordyn Phelps and Anne Flaherty contributed to this report.

This report was featured in the Tuesday, March 24, 2020, episode of “Start Here,” ABC News’ daily news podcast.

\"Start Here\" offers a straightforward look at the day's top stories in 20 minutes. Listen for free every weekday on Apple Podcasts, Google Podcasts, Spotify, the ABC News app or wherever you get your podcasts.

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