On Sunday, senators voted along party lines to quash a Democratic filibuster of Barrett to replace the late liberal icon, Justice Ruth Bader Ginsburg. Collins, R-Maine, and Sen. Lisa Murkowski, R-Alaska, joined Democrats in the vote.

Murkowski had initially opposed moving a nominee so close to the election, saying \"fair is fair\" given that her own party had blockaded President Barack Obama's pick in 2016 to replace the late Justice Antonin Scalia eight months before the election, but with Republicans securing the necessary votes for confirmation, Murkowski has changed course.

Sen. Cory Booker slams Republicans ahead of an expected vote to confirm judge Amy Coney Barrett to the Supreme Court: \"And yet we are going through instead of waiting to listen to our fellow Americans showing that grace, that they should decide.\" https://t.co/luKB9T5aUu pic.twitter.com/Yw2aL81k0M

— ABC News Politics (@ABCPolitics) October 26, 2020

\"While I oppose the process that has led us to this point,\" Murkowski said in a Saturday floor speech. \"I do not hold it against her as an individual who has navigated the gauntlet with grace, skill and humility.\"

That move left Collins alone among the GOP opposition who voted against Barrett on Monday. Collins is in an extremely difficult fight for reelection in a moderate state where she has been lambasted for her past support of conservative jurists, including Trump's highly contentious nominee, Justice Brett Kavanaugh.

ABC News' John Santucci, Katherine Faulders and Lauren King contributed to this report.

This report was featured in the Tuesday, Oct. 27, 2020, episode of “Start Here,” ABC News’ daily news podcast.

\"Start Here\" offers a straightforward look at the day's top stories in 20 minutes. Listen for free every weekday on Apple Podcasts, Google Podcasts, Spotify, the ABC News app or wherever you get your podcasts.

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