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“For the past two weeks, you have been reading about a bad break,” he said. “Yet today I consider myself the luckiest man on the face of the Earth.”

Gehrig would pass away on June 2, 1941, at the age of 37.

During the fourth inning of Wednesday's games, stadiums will play a video narrated by Hall of Famer Cal Ripken Jr., who broke Gehrig's consecutive game record in 1995, that highlights ALS advocate Steve Gleason.

\"PHOTO:
Bettmann Archive/Getty Images, FILE
PHOTO: Lou Gehrig of the New York Yankees.
>

Gleason, who has lost the ability to speak because of the disease, will recite Gehrig's retirement speech using technology from Google's Project Euphonia that allows a person to speak with their own voice through a device.

Each team will also have other programs during the game to honor local ALS advocates.

The New York Yankees will honor the families of Pat Quinn and Pete Frates, the co-creators of the 2014 ALS Ice Bucket Challenge. The Miami Marlins will auction off signed baseballs, with all proceeds going to the University of Miami’s ALS Center.

Fans will also be encouraged to donate money the Healy Center for MLS at mlb.com/4ALS.

Gehrig is the third MLB player to have a day reserved in their honor across the league after Jackie Robinson and Roberto Clemente.

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