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Saturday marked the fourth consecutive day of more than 100,000 new daily COVID-19 cases in the U.S., according to the Centers for Disease Control and Prevention. And Friday, the U.S. recorded its highest daily COVID-19 case count in six months, with more than 120,000 new cases reported.

And though more than 50% of Americans are fully vaccinated and that rate increased by 25% in the last week, according to the CDC, due to the rapidly spreading delta variant, some states and counties have reimplemented mitigation strategies, such as mask mandates.

Collins at first did not give a direct answer on whether he believed more vaccine mandates should be implemented, initially saying he celebrates when businesses decide to require vaccinations for employees.

\"As a person who runs the National Institutes of Health with 45,000 employees and contractors, I am glad to see the president insisting that we go forward requiring vaccinations or if people are unwilling to do that, then regular testing, at least once or twice a week, which will be very inconvenient,\" Collins said.

\"I think we ought to use every public health tool we can when people are dying,\" Collins added.

\"That was about as close as a yes as you could get. You clearly believe that vaccine mandates could make a difference,\" Stephanopoulos pressed.

\"I do believe they should make a difference,\" Collins responded. \"I understand how that can sometimes set off all kinds of resistance. But isn't that a shame?\"

.@GStephanopoulos asks @NIHDirector his best advice for parents.

\"Think about masks in the way that they ought to be thought about: this is not a political statement or an invasion of your liberties. This is a lifesaving medical device.\" https://t.co/KfLFZu3Wd8 pic.twitter.com/G6BtGJxemH

— This Week (@ThisWeekABC) August 8, 2021

If more people had gotten vaccinated when vaccines became widely available, the current surge fueled by the delta variant could have been mitigated, Collins said earlier in the interview, responding to a USA TODAY front page headline: \"We are failing one another.\"

\"I'm afraid we should not really have ever gotten in the place we are,\" Collins said. \"In that regard, yes, we are failing. ... Now we're paying the terrible price.\"

As more children are currently hospitalized than at any other point in the pandemic, Stephanopoulos asked Collins whether the delta variant is more serious for children.

\"We don't have rigorous data to show for sure,\" Collins responded. \"But this is a virus that is not only more contagious, but potentially more lethal.\"

With the school year set to begin across the nation, Collins said he would ask parents to think about masks as a \"life-saving medical device\" and ask their children to wear them.

\"We know that kids under 12 are likely to get infected and if we don't have masks in schools, this virus will spread more widely,\" Collins told Stephanopoulos. \"It will probably result in outbreaks in schools and kids will have to go back to remote learning which is the one thing we really want to prevent.\"

\"It's a small price to pay for being able to keep kids where they need to be to learn,\" Collins added.

.@GStephanopoulos asks @NIHDirector his best advice for parents.

\"Think about masks in the way that they ought to be thought about: this is not a political statement or an invasion of your liberties. This is a lifesaving medical device.\" https://t.co/KfLFZu3Wd8 pic.twitter.com/G6BtGJxemH

— This Week (@ThisWeekABC) August 8, 2021

While the current vaccines have high efficacy in stopping the spread of the highly contagious delta variant, Collins said he worries about \"the day when a variant arises that is so different from the original Wuhan virus\" that it evades the current vaccines and requires the quick development of a booster shot.

\"The best way to prevent that from happening is to reduce the number of infections because that's how mutants happen. It's because people are infected with the virus and it copies itself slightly wrong and then you get something that's even worse,\" Collins said.

.@NIHDirector tells @GStephanopoulos that health officials \"don't have anxieties yet\" about vaccines not protecting against other COVID-19 variants.

\"The best way to prevent that from happening is to reduce the number of infections.\" https://t.co/KfLFZu3Wd8 pic.twitter.com/YjfrQldu0Q

— This Week (@ThisWeekABC) August 8, 2021

As the country awaits the Food and Drug Administration's full approval of the COVID-19 vaccines, Collins said he has been in close contact with the agency and they hope to issue full authorization within the next month.

\"But meanwhile, while people are waiting for that -- and I understand that would help -- please be clear about this, the vaccines have incredible evidence for their safety and effectiveness. They work against delta. They will save your life,\" Collins said.

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