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Multiple evacuation orders and warnings are in place as Cal Fire warns of a \"dangerous rate of spread\" for the wildfire.

Among the largest active blazes in the state, the Route Fire has burned more than 5,000 acres in Castaic in Los Angeles County since igniting on Wednesday. It was nearly 40% contained as of Friday morning.

The Border 32 Fire in San Diego County has also burned more than 4,400 acres since Wednesday. It was 20% contained as of Friday morning.

ABC News' Jennifer Harrison, Daniel Amarante and Max Golembo contributed to this report.

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