More than 260,000 people in the United States have now died from COVID-19, according to a real-time count kept by Johns Hopkins University.

The country hit the grim milestone on Wednesday.

The nationwide, cumulative total currently stands at 12,613,248 confirmed cases of COVID-19 and at least 260,190 deaths, according to Johns Hopkins data. The cases include people from all 50 U.S. states, Washington D.C. and other U.S. territories as well as repatriated citizens.

The United Parcel Service (UPS) said it will start making dry ice in its U.S. facilities and will provide portable freezers to aid in the massive distribution efforts for COVID-19 vaccines in the coming months.

The Atlanta-based global shipping and logistics company said it can now produce up to 1,200 lbs of dry ice per hour in its U.S. facilities to support the storage and transportation of cold chain products, such as frozen vaccines, in accordance with manufacturer storage requirements. The increased production also allows UPS to make dry ice available for American and Canadian hospitals, clinics and other points of care requiring dry ice to store vaccines locally.

"Enhancing our dry ice production capabilities increases our supply chain agility and reliability immensely when it comes to handling complex vaccines for our customers," Wes Wheeler, president of UPS's new healthcare logistics unit, said in a statement Tuesday. "Healthcare facilities in Louisville, Dallas and Ontario will ensure we have the capability to produce dry ice to sufficiently pack and replenish shipments as needed to keep products viable and effective."

In addition to dry ice production, UPS is teaming up with Stirling Ultracold, a division of Global Cooling, Inc., to supply portable ultra-low temperature freezers to thermally protect critical vaccines requiring temperatures ranging from -20 to -80 degrees Celsius. The portable freezers will be distributed and used in smaller facilities that need a more permanent solution for longer-term freezer storage.

"This program will help ensure vaccines remain effective next year, and for years to come, as future vaccines and biologics are developed to keep the world healthy and safe," Stirling Ultracold CEO Dusty Tenney said in a statement Tuesday.

Some 778,000 workers lost their jobs and filed for unemployment insurance last week, the Department of Labor said Wednesday. 

This is an uptick of 30,000 compared to the previous week, and the second consecutive week that the weekly tally has risen after it was on the decline for months. 

The DOL also said Wednesday that more than 20 million people were still receiving some form of unemployment benefits through all programs as of the week ending Nov. 7. For the comparable week in 2019, that figure was 1.5 million. 

The latest economic data from the DOL comes as new virus cases surge across the country, and highlight a slow economic recovery. It also comes, however, as Dow Jones Industrial Average hit a new milestone of trading above 30,000 on Tuesday -- a further indication that the stock market remains divorced from the economic pain millions of Americans still face as the coronavirus crisis rages on. 

ABC News’ Catherine Thorbecke contributed to this report.

America's top infectious disease expert is urging the nation to keep indoor gatherings as small as possible over Thanksgiving to prevent further spread of the novel coronavirus.

"We all know how difficult that is because this is such a beautiful, traditional holiday. But by making that sacrifice, you're going to prevent people from getting infected," Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, told ABC News chief anchor George Stephanopoulos in an interview Wednesday on "Good Morning America."

"A sacrifice now could save lives and illness and make the future much brighter as we get through this," he continued. "We're going to get through this. Vaccines are right on the horizon. If we can just hang in there a bit longer and continue to do the simple mitigation things that we're talking about all the time -- the masks, the distancing, the avoiding crowds, particularly indoor. If we do those things, we're going to get through it. So that's my final plea before the holiday."

Fauci, a leading member of the current White House coronavirus task force, warned of "yet another surge" of COVID-19 infections if people don't heed his advice over the holiday.

Although he acknowledged that the country's current surge in cases is driven by larger indoor gatherings such as bars, Fauci noted that "there still is transmission among gatherings that appear to be relatively innocent."

"Now, I don't mean two, three, four people in a room. We're talking about when people might have a modest size and let their guard down," he added. "When you stay away from the bars, when you stay away from the big, congregate settings, there still is a danger if you bring people into the home who are not part of the immediate household. There is a risk there."

Fauci also said he is "greatly" concerned by the number of people who are already showing hesitancy to taking a COVID-19 vaccine when it becomes available. He noted that "independent bodies of people who, in fact, have no allegiance to an administration or to a company" will be charged with deciding whether the vaccine is both safe and effective for the public.

"The process by which the vaccines were made were a standard process that was rapid because of exquisite scientific advances and the investment of an extraordinary amount money. It did not compromise safety and it did not compromise scientific integrity," he said. "That's what the public needs to understand, that the process is transparent and its independent."

The solution to the coronavirus pandemic, Fauci said, will be "a combination of public health measures and a safe and effective vaccine."

"It would really be terrible if we have, which we do, three now and maybe more highly efficacious vaccines and people don't take it," he added. "We could crush this outbreak exactly the way we did years ago with smallpox, with polio and with measles. It is doable."

At least 26 U.S. states and the nation's capital have seen the seven-day average of their daily COVID-19 cases double since the beginning of the month, according to an ABC News analysis of trends across the country.

In addition to Washington D.C., those 26 states are Arizona, California, Colorado, Connecticut, Delaware, Indiana, Kansas, Louisiana, Maryland, Michigan, Minnesota, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, Ohio, Oklahoma, Oregon, Pennsylvania, Utah, Vermont, Washington, West Virginia and Wyoming.

The national monthly tally of cases also continues to increase rapidly. There have been at least 20 straight days where the country as a whole has confirmed more than 100,000 new cases in a 24-hour reporting period. Over 3.1 million cases have been confirmed so far in just the month of November, which would be roughly the equivalent to a theoretical scenario where the entire state of Utah had tested positive for COVID-19 in the last three weeks.

Meanwhile, the number of COVID-19 patients hospitalized across the United States has doubled in the past month, with 12 states reporting a record number of hospitalizations on Monday.

The United States is now averaging more than 1,500 new COVID-19 fatalities every day, a rate of more than one death reported per minute. The national seven-day average of daily deaths is also now twice as high as it was just a month ago.

The trends were all analyzed from data collected and published by the COVID Tracking Project over the past two weeks, using the linear regression trend line of the seven-day moving average.

ABC News' Benjamin Bell, Brian Hartman, Soorin Kim and Arielle Mitropoulos contributed to this report.