As heart, kidney and metabolic health worsen, cancer risk may rise: Study
As heart, kidney and metabolic problems progress to more advanced stages, a person's risk of developing several cancers also rises sharply, a new study finds.
Cardiovascular-kidney-metabolic (CKM) syndrome is a disorder that occurs when heart disease, kidney problems and metabolic issues including obesity and diabetes all happen together, according to the American Heart Association.
About one in three U.S. adults have at least three risk factors for CKM syndrome, the AHA says.
Researchers used a claims database in Japan that included individuals with available health check-up data and insurance claims between April 2014 and August 2023.
People diagnosed with stage 3 CKM syndrome at the start of the study were 25% more likely to be diagnosed with one of 16 different cancers four years later in comparison to those with early CKM syndrome, according to the study published Monday in the journal Circulation.
Those who were diagnosed with stage 4 CKM syndrome had a 30% increased likelihood of having a cancer diagnosis four years later. Those diagnosed with stage 1 or stage 2 of the condition had a less than 5% chance of cancer diagnosis in four years.
"The study findings suggest that it is important to consider not only cardiovascular disease risk, but also cancer risk in people with CKM syndrome," Dr. Hidehiro Kaneko, the study's lead author and associate professor in the department of cardiovascular medicine at the University of Tokyo in Japan, said in a press release.
The study results accounted for age, gender and lifestyle factors including smoking, alcohol use and weight.
Individual symptoms such as high blood pressure are often used to determine certain cancer risks, but this study used a more patient-centered classification such as CKM syndrome staging as a predictor for certain cancers, according to the authors.
"CKM syndrome represents a complex interplay among the cardiovascular, kidney and metabolic systems, where dysfunction in one area may trigger or exacerbate dysfunction in others," Kaneko said.
"Dysfunction in each of these systems is independently associated with cancer risk due to shared risk factors," he continued. "This study suggests that the accumulation of risk factors within the framework of CKM syndrome may contribute to the development of various types of cancer."
Because the study is a retrospective observational study, meaning it analyzes existing data, it can only speak to association between CKM syndrome and certain cancers, not causality.
Additionally, because the study was conducted in Japan, which has a very homogenous population, further research would be needed to replicate the results among the U.S. population, which is more diverse.
Dr. Taiwo Ajumobi is a pediatric resident at Goryeb Children's Hospital in Morristown, New Jersey and a member of the ABC News Medical Unit.
