The MV Hondius cruise ship has set sail from Spain after evacuating passengers and crew from 23 countries, Spanish health minister Monica Garcia said.

"Mission accomplished. Thank you to everyone who made this possible. We continue working to protect public health,” Garcia said.

Eight French nationals who shared a flight with a sick person 15 days ago are now in isolation at a hospital in France, French Prime Minister Sébastien Lecornu said. None of the eight have symptoms, he said.

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This is in additional to the five French nationals who returned to France on Sunday from the cruise ship and are in isolation at Bichat Hospital in Paris. Four are still testing negative, while the one who tested positive for hantavirus is in intensive care in stable condition, the prime minister said.

-ABC News' Will Gretsky

In the coming days, as the cruise ship passengers decide whether to stay at the University of Nebraska quarantine facility or self-monitor at home, those who opt to go home will not fly on a commercial flight, an official from the Centers for Disease Control and Prevention told ABC News. Passengers who opt to go home will have been assessed by health officials for any signs of illness.

-ABC News’ Youri Benadjaoud

President Donald Trump discussed the hantavirus outbreak on Monday, saying, "We think we're in very good shape. We're very careful."

“It’s been around for a long time," he said of the hantavirus. "People are very familiar with it. So, you know, I hope it's fine."

“All I can do is, everything that a president can do, which is something which is actually somewhat limited,” he continued.

Trump also defended his withdrawal from the World Health Organization earlier this year, saying he is “glad” he made this decision.

“No, I’m glad,” Trump said when asked if he regrets withdrawing from WHO.

“We weren't being treated well, and they were making the wrong diagnoses,” he claimed, later arguing that the organization either “lied” to him or “didn’t know.”

-ABC News’ Emily Chang

On Monday, 16 American cruise ship passengers arrived at the University of Nebraska Medical Center; 15 are in the quarantine unit and one person who tested positive is in the biocontainment unit.

Three of those passengers now in Nebraska are residents of New York, according to New York state Health Commissioner Dr. James McDonald.

“One passenger is from New York City, while the other two are residents of Orange County and Westchester County. All three are expected to be subject to a 42-day monitoring period," McDonald said in a statement.

“It is important to emphasize that there is no immediate risk to the public,” McDonald added.