The Centers for Disease Control and Prevention said it deployed a team earlier Friday to the Canary Islands, where the M/V Hondius is expected to dock in the coming days.

"The team will conduct an exposure risk assessment for each American passenger and provide recommendations for the level of monitoring required," the CDC said in a statement.

The American passengers will be evacuated on a U.S. government medical repatriation flight to Nebraska and transported to a quarantine center at the University of Nebraska in Omaha, the CDC said.

Another CDC team will deploy to Offutt Air Force Base in Bellevue, Nebraska, to "support public health assessment of returning passengers," the agency said.

Oceanwide Expeditions provided an update about the 87 guests and 60 crew member aboard the M/V Hondius Friday and said the situation on board "remains calm," as it heads to the Canary Islands.

The boat is scheduled to arrive early Sunday, but that timetable is subject to change, according to Oceanwide.

"Preparations regarding our point of arrival, quarantine and screening procedures for all guests, and the onward travel plans for all guests and affected crew are being led by organizations from a number of countries, including the WHO, RIVM, and Dutch authorities, in close cooperation with Spanish government authorities," Oceanwide said in a statement.

The cruise company provided a breakdown of the ship's passengers and crew and revealed there are 17 Americans aboard the ship.

-ABC News' Claire Bower

Several American passengers from the cruise ship associated with a suspected hantavirus cluster are set to arrive at a quarantine unit in Nebraska over the next few days. Here's what to know about the facility.

The National Quarantine Unit, managed by Nebraska Medicine and the University of Nebraska Medical Center (UNMC), is the only federally funded quarantine unit in the U.S.

Its 20 single-occupancy rooms with en-suite bathrooms contain individual negative air pressure systems to safely house individuals exposed to highly hazardous communicable diseases, according to Nebraska Medicine and UNMC.

The rooms also contain exercise equipment and WiFi connectivity for patients requiring longer stays.

Nebraska Medicine and UNMC also manage the Nebraska Biocontainment Unit (NBU), which provides medical care to patients with highly hazardous communicable diseases.

“Unit personnel consists of a voluntary staff of select physicians, nursing, nursing assistants and respiratory therapists specially trained in high-level isolation and bio preparedness,” Nebraska Medicine and UNMC said on its website.

The NBU was activated in 2014 to care for U.S. citizens affected by the Ebola outbreak and medically evacuated from Africa and during the COVID-19 pandemic in 2020 to care for U.S. citizens from Wuhan, China, and the Diamond Princess Cruise ship.

The University of Nebraska, which hosts the quarantine facility the American cruise ship passengers are set to travel to, said Nebraska Medicine and the University of Nebraska Medical Center (UNMC) are coordinating with partners to receive the U.S. citizens.

The university said the National Quarantine Unit is the only federally funded quarantine unit in the U.S.

"We are prepared for situations exactly like this," Dr. Michael Ash, CEO of Nebraska Medicine, said in a statement. "Our teams have trained for decades alongside federal and state partners to make sure we can safely provide care while protecting our staff and the broader community. We are proud to support this national effort."

Nebraska Medical Center also houses the Nebraska Biocontainment Unit, a highly specialized facility meant to care for patients with "high-consequence infectious diseases," the university said.

Nebraska Medicine and UNMC treated patients during the 2014 Ebola outbreak and cared for some of the first Americans diagnosed with COVID-19 in 2020.

"We understand situations like this can raise questions," Ash said. "People should know these facilities were specifically designed to prevent exposure to the public. There is no risk to the community from people being cared for in these units."

In a statement released earlier on Thursday, the University of Nebraska said both units "are staffed and ready, if needed, to safely provide care while protecting our staff and the community."

-ABC News' Youri Benadjaoud