Mahmoud Abbas, president of the State of Palestine, is pulling out of his Wednesday meeting with President Joe Biden.

"President Mahmoud Abbas decided to return to the homeland tonight, and he called for an emergency leadership meeting tonight," a senior adviser said Tuesday.

Biden is expected to leave the U.S. Tuesday night to head to Israel and Jordan.

-ABC News' Will Gretsky

At least 500 people have been killed in an explosion at Al Ahli Arab Hospital in the middle of Gaza, according to the Gaza Health Ministry.

The hospital served as a shelter for thousands of residents who fled their homes in northern Gaza.

The Israel Defense Forces denied responsibility for the explosion, saying a failed launch by the Palestinian Islamic Jihad caused the blast.

"From the analysis of the operational systems of the IDF, an enemy rocket barrage was carried out towards Israel, which passed in the vicinity of the hospital, when it was hit," IDF said.

The World Health Organization condemned the blast and called for "the immediate active protection of civilians and health care" workers.

This hospital "was one of 20 in the north of the Gaza Strip facing evacuation orders from the Israeli military," the WHO said in a statement. "The order for evacuation has been impossible to carry out given the current insecurity, critical condition of many patients, and lack of ambulances, staff, health system bed capacity, and alternative shelter for those displaced."

Palestinian Authority President Mahmoud Abbas has declared three days of mourning following the attack.

-ABC News' Will Gretsky

Israeli National Security Adviser Tzachi Hanegbi said Tuesday that officials plan to create "safe zones" in southern Gaza as the only places where residents can receive humanitarian aid.

The aid would be "on one condition," Hanegbi said in Hebrew. "If this aid does not reach civilians, but goes to murderers, [the safe zones] will simply not exist."

The Rafah border crossing between Egypt and Gaza has now endured four bombings from Israel, according to a spokesperson for Egypt's Ministry of Foreign Affairs.

The Rafah crossing was shut on Oct. 10 after it was hit by Israeli warplanes on the Palestinian side three times on Oct. 9 and 10.

"We are in constant contact with all U.N. agencies to extract a safe passage for the relief aid," Egyptian Foreign Minister Sameh Shoukry told BBC Radio. "There is not yet any sort of authorization for a safe passage from the other side of the crossing.”

Shoukry also called out Israeli leaders who urged Gaza residents to move south, saying, "Israel’s call for displacement to the South is in full contradiction to international humanitarian law, leaving people with no water, electricity or food."

In his first on-camera comments about Israel’s evacuation request for northern Gaza, Israeli Defense Minister Yoav Gallant urged Gaza residents to head south. He noted that Hamas will use them as "camouflage," “therefore we need to separate them."

"Those who want to save their life, please go south. We are going to destroy Hamas infrastructures, Hamas headquarters, Hamas military," he said.

Defense Secretary Lloyd Austin, who appeared at the press conference with Gallant, dodged ABC News' question about how Israel could end the Hamas terror threat without inevitably risking civilian lives. Austin called Israel's military "professional" and "disciplined."

Austin described how ISIS had also embedded themselves in civilian populations and how the anti-ISIS coalition "protected civilians and created corridors for humanitarian movement even in the midst of a pretty significant fight. So again, this is a professional force. It is well led, and I have every expectation that it will be disciplined."

Austin added, "I would tell you that in countering ISIS, I felt as if we were staring evil in the eye, it was truly evil. And what we've seen from Hamas, it takes that evil to another level."

-ABC News' Matt Seyler and Luis Martinez