Slotkin discussed the despair that many Americans are feeling and their anger over leaders who have not stood up to Trump and his administration.

"Hold your elected officials, including me, accountable. Watch how they're voting. Go to town halls and demand they take action. That's as American as apple pie," she said.

The senator also pushed Americans to organize.

"Pick just one issue you're passionate about and engage. And doomscrolling doesn't count. Join a group that cares about your issue and act. And if you can't find one, start one. Some of the most important movements in our history have come from the bottom up," she said.

Democrat Elissa Slotkin slammed Trump over last week's Oval Office dust-up between Trump, Vance and Ukraine's Volodymyr Zelenskyy, saying Ronald Reagan "must be rolling in his grave."

"We all want an end to the war in Ukraine. But Reagan understood that true strength required America to combine our military and economic might with moral clarity," she said. "And that scene in the Oval Office wasn't just a bad episode of reality TV. It's summed up Trump's whole approach to the world."

Slotkin said Trump "believes in cozying up to dictators like Vladimir Putin and kicking our friends like the Canadiens in the teeth."

Slotkin criticized DOGE and Trump for the "mindless" mass firings of federal workers, only to hire some of them back days later.

"No CEO in America could do that without being summarily fired," she said.

"Is there anyone in America who is comfortable with him and his gang of 20 year olds using their own computer servers to poke through your tax returns, your health information and your bank accounts?" Slotkin asked while delivering remarks on economic security.

While she agreed that America needs a more efficient government, she argued that there is "no oversight" with Musk's efforts.

Democratic Reps. Sydney Kamlager-Dove and Maxwell Frost released statements after they left the speech.

"Through walking out, my message to Donald Trump is simple: stop the lies, stop the cheating, and stop the stealing -- enough is enough. The American people deserve better," Kamlager-Dove said.

"Donald Trump is many things -- a liar, a grifter, a wanna-be-dictator -- but no matter how hard he tries and how many Republicans in Congress bend the knee and kiss the ring: he will never be king," Frost said.

-ABC News' John Parkinson