Britain's Queen Elizabeth II died hours after Buckingham Palace announced she was "under medical supervision" because "doctors are concerned" about her health.
"The Queen died peacefully at Balmoral this afternoon," the royal family said in a statement Thursday evening local time.
Earlier in the day, the palace announced she was under medical supervision "following further evaluation" that morning.
The 96-year-old monarch had spent the summer at Balmoral Castle, the royal family's estate in Aberdeenshire, Scotland. A royal source told ABC News earlier on Thursday that immediate family members had been informed of the situation.
MORE: Queen Elizabeth, longest-reigning British monarch, dies at 96The queen's oldest child, Charles, Prince of Wales; and his wife, Camilla, Duchess of Cornwall; as well as the queen's daughter, Princess Anne, were at Balmoral, according to their respective spokespersons. The queen's other sons, Prince Andrew, Duke of York; and Prince Edward, Earl of Wessex; as well as Edward's wife, Sophie, Countess of Wessex; Charles' two sons, Prince William, Duke of Cambridge; and Prince Harry, Duke of Sussex began to make their way to Balmoral, their respective spokespersons confirmed earlier Thursday.
On Wednesday, the queen canceled a meeting of her Privy Council and was told to rest, a source at Buckingham Palace told ABC News. At the time, the palace would not comment on the queen's health beyond saying she was heeding doctors' advice to rest.
After the palace's announcement of her health on Thursday morning, U.K. Prime Minister Liz Truss took to Twitter to say that her "thoughts -- and the thoughts of people across our United Kingdom -- are with Her Majesty The Queen and her family at this time."
"The whole country will be deeply concerned by the news from Buckingham Palace this lunchtime," Truss tweeted.
Truss, who was recently selected as the new leader of the U.K.'s ruling Conservative Party, had an audience with the queen at Balmoral Castle on Tuesday, during which she was formally asked to form a new government as prime minister after Boris Johnson's official resignation. It was the first time in the queen's 70-year reign that the ceremonial transfer of power was held at Balmoral, rather than at Buckingham Palace in London.
MORE: Queen Elizabeth II ends Platinum Jubilee the same way she began her reign 70 years agoThe queen faced several health conditions over the past year, including COVID-19 and an overnight hospitalization for what Buckingham Palace described at the time as "preliminary investigations."
In July, British newspaper The Telegraph reported that Buckingham Palace changed the details of the queen's job description in its annual report by swapping out the "Queen's programme" of engagements for more general "visits in royal programmes." Instead, members of the royal family, including Charles, the heir apparent to the British throne, would step in and support some of her duties.
A palace source told ABC News at the time that these changes were not "drastic" but a small update. The Sovereign Grant report indicated that the queen's role still comprised two key elements: Head of State and Head of Nation, which means that as Head of State, she "must fulfill" specific duties.
In May, Charles stepped in for his mother when she missed the opening of Parliament due to mobility issues. It was the first time in six decades that she was not present. Instead, her crown was placed next to Charles.