The steamy love lives of the doctors on TV at Grey Sloan Memorial Hospital have kept fans pulses racing for over a decade.
The beloved series "Grey's Anatomy" will make history this week as it takes its place Thursday as the longest-running primetime medical drama of all time.
In honor of the milestone, "Good Morning America" spoke to some of the cast members about the series' most iconic love stories.
Since the very beginning, Meredith Grey and Derek "McDreamy" Shepard's whirlwind romance that had us at the edge of our seats.
We certainly want to convey to our young fans that you don't need the approval of someone's love to make you whole -- or to make you matter.
And season 15 is no different, with many of our favorite characters still blissfully in love.
Like Jo and Alex Karev, who are now onscreen husband and wife.
But was Camilla Luddington charmed by him before joining the cast?
"No, Alex Karev was a jerk," Luddington said in an interview with ABC News' Juju Chang.
Sandra Oh makes history as 1st Asian actress to host Golden Globes, then wins award later in night
- Jan 06, 2019
Ellen Pompeo congratulates former 'Grey's Anatomy' co-star Sandra Oh on her Golden Globes win
- Jan 09, 2019
But some of those signature "Grey's Anatomy" love triangles are still causing hearts to skip a beat.
Actress Kim Raver, who plays Teddy Altman, said the show really paved the way for showing these kind of situations on television.
"I mean, 15 years in and I feel like we're doing a love triangle ... that's never really kind of been done this way," she said. "And that's what's really great is all these people are human and they all are making mistakes, like we all are in the real world."
Giacomo Gianniotti, who plays Dr. Andrew DeLuca, spoke out about the love triangle he caused for Meredith Grey, saying he knows if he breaks her character's heart, people will come after him.
"People will come to my door. I'm afraid," Gianniotti said. "I'm very trying not to break her heart for a lot of reasons, personal reasons."
When asked if her character will find love, Ellen Pompeo, who plays Meredith Grey, said one of the ultimate messages of the show "is that no woman really needs a man."
"Well I think the message we want to send for sure is that no woman really needs a man. I mean, men or women or partners are nice, but we don't need them," she said. "Ultimately that's the message we want to convey. And we certainly want to convey to our young fans that you don't need the approval of someone's love to make you whole -- or to make you matter. But, I think, you know, love is fun and love ultimately, I think, is what we're all doing on this planet."