• Video
  • Shop
  • Culture
  • Family
  • Wellness
  • Food
  • Living
  • Style
  • Travel
  • News
  • Book Club
  • GMA3: WYNTK
  • Newsletter
  • Privacy Policy
  • Your US State Privacy Rights
  • Children's Online Privacy Policy
  • Interest-Based Ads
  • Terms of Use
  • Do Not Sell My Info
  • Contact Us
  • © 2025 ABC News
  • Culture

Demi Moore, Dennis Quaid, Margaret Qualley star in 'The Substance' trailer: See here

1:08
Demi Moore talks about the ‘vulnerability’ needed to film the nude scenes in new film
Mubi
ByAngeline Jane Bernabe
August 15, 2024, 10:35 PM

The official trailer for "The Substance" is here.

The highly anticipated film stars Demi Moore, Margaret Qualley and Dennis Quaid in a story about toxic beauty culture.

Related Articles

Demi Moore and Margaret Qualley star in action-packed new teaser for 'The Substance': Watch here

In the Coralie Fargeat-directed film, Moore plays Elisabeth Sparkle, "a former A-lister past her prime and suddenly fired from her fitness TV show by repellent studio head Harvey (Quaid)," according to a synopsis.

Demi Moore appears in the official trailer for Coralie Fargeat's "The Substance."
Mubi

"She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE," the synopsis continues. "All it takes is one injection and she is reborn -- temporarily -- as the gorgeous, twentysomething Sue (Qualley)."

The only catch is that once the substance is taken, "time needs to be split: exactly one week in one body, then one week in the other. No exceptions."

Margaret Qualley appears in the official trailer for Coralie Fargeat's "The Substance."
Mubi

In the trailer, we see Moore's character transform into Sue. Things take a turn when Moore's character is on the phone and says that "there's been a slight misuse of the substance."

"Going into it, it was really spelled out the level of vulnerability and rawness that was really required to tell this story," Moore said about the film in May. "It was a very vulnerable experience and just required going into it with a sensitivity and a lot of conversion about what we were trying to accomplish, how we were going to approach it."

Related Articles

Demi Moore talks about the 'vulnerability' needed to film the nude scenes in new film

Moore also called Qualley a "great partner" during filming.

Dennis Quaid appears in the official trailer for Coralie Fargeat's "The Substance."
Mubi

"We were obviously close in certain moments -- naked," Moore said. "It allowed us also a lot of levity in those moments at how absurd those certain situations were with us laying on the tile floor. But ultimately, it's just about I think really direct and clear communication and mutual trust."

"The Substance" arrives in theaters on Sept. 20.

Up Next in Culture—

'Bachelor' star Grant Ellis, Juliana Pasquarosa part ways, say they still 'love and respect' each other

June 13, 2025

Taylor Swift and Travis Kelce attend Game 4 of NHL Stanley Cup Final in Florida

June 13, 2025

'GMA' co-anchors, crew say goodbye to Times Square

June 13, 2025

Eric Dane opens up about ALS diagnosis: 'I don't think this is the end of my story'

June 13, 2025

Shop GMA Favorites

ABC will receive a commission for purchases made through these links.

Sponsored Content by Taboola

The latest lifestyle and entertainment news and inspiration for how to live your best life - all from Good Morning America.
  • Contests
  • Terms of Use
  • Privacy Policy
  • Do Not Sell My Info
  • Children’s Online Privacy Policy
  • Advertise with us
  • Your US State Privacy Rights
  • Interest-Based Ads
  • About Nielsen Measurement
  • Press
  • Feedback
  • Shop FAQs
  • ABC News
  • ABC
  • All Videos
  • All Topics
  • Sitemap

© 2025 ABC News
  • Privacy Policy— 
  • Your US State Privacy Rights— 
  • Children's Online Privacy Policy— 
  • Interest-Based Ads— 
  • Terms of Use— 
  • Do Not Sell My Info— 
  • Contact Us— 

© 2025 ABC News