© 2026 ABC News

\"Grey's Anatomy,\" created by Rhimes, premiered on March 27, 2005, and is currently airing its milestone 20th season on ABC.

The series, the longest-running primetime medical drama, has given TV fans beloved female characters like Meredith Grey (Ellen Pompeo), Cristina Yang (Sandra Oh), Izzy Stevens (Katherine Heigl), and Miranda Bailey (Chandra Wilson) -- and those are just the series regulars from season 1.

\"PHOTO:
Liliane Lathan/ABC via Getty Images
PHOTO: Ellen Pompeo as Dr. Meredith Grey on "Grey's Anatomy."
>

Someone tell Rhimes' daughter to buckle up and prepare to have her heart broken -- remember that season 5 finale? -- and put back together -- blue post-it note, anyone? -- over and over again.

\"Grey's Anatomy\" airs Thursdays at 9 p.m. ET on ABC, with episodes streaming on Hulu the following day.

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