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Chambers is one of the original \"Grey's Anatomy\" cast members, playing Alex Karev from the show's very beginning in 2005.

His character departed midway through season 16 -- in the milestone 350th episode -- as he left Seattle to start his life with former flame Izzie Stevens (Katherine Heigl) and their children.

Leigh played Lexie Grey -- the little sister of the show's central character, Meredith Grey (Ellen Pompeo) -- from season 3 to season 8.

Despite her tragic death on the show in a tragic plane crash, Leigh returned for a cameo during season 17 during a dream sequence while Meredith was in a COVID-induced coma.

\"Grey's Anatomy\" has been renewed for a landmark 21st season.

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