Mickey Guyton made history at the 55th Academy of Country Music Awards on Wednesday night.

The country star, 37, performed her hit, "What Are You Gonna Tell Her?" with Keith Urban on piano, making her the first Black female country artist to perform her own song at the Academy of Country Music Awards.

The historical moment, live from the Grand Ole Opry House in Nashville, was Guyton's solo ACM Award performance debut.

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PHOTO: Mickey Guyton performs onstage during the 55th Academy of Country Music Awards at the Grand Ole Opry on Sept. 16, 2020 in Nashville, Tenn.
Jason Kempin/Getty Images
Mickey Guyton performs onstage during the 55th Academy of Country Music Awards at the Grand Ole Opry on Sept. 16, 2020 in Nashville, Tenn.

Many were taken by the emotional lyrics and the message behind Guyton's song, "What Are You Gonna Tell Her?"

Some of the lyrics include: "She thinks life is fair and / God hears every prayer / And everyone gets their ever after / She thinks love is love and if / You work hard, that's enough / Skin's just skin and it doesn't matter / And that her friend's older brother's gonna keep his hands to himself / And that somebody's gon' believe her when she tells."

"But what are you gonna tell her / When she's wrong," the lyrics continue. "Will you just shrug and say it's been that way all along / What are you gonna tell her / When she figures out / That all this time you built her up just so the world could let her down."

Guyton previously described the song as a "call to action" during an interview with CMT earlier this year.

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PHOTO: Keith Urban and Mickey Guyton perform onstage during the 55th Academy of Country Music Awards at the Grand Ole Opry on Sept. 16, 2020 in Nashville, Tenn.
Jason Kempin/Getty Images
Keith Urban and Mickey Guyton perform onstage during the 55th Academy of Country Music Awards at the Grand Ole Opry on Sept. 16, 2020 in Nashville, Tenn.

She said she wrote the song after a 15-year-old girl messaged her on social media asking for advice.

"She was like, 'I’m moving to Nashville I’m gonna go to Belmont and what do I have to look forward to as a country music singer?' I didn’t have anything to tell her," Guyton explained. "And that’s a big problem."

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"I wanted to write about it," she added. "I wrote the song about changing things so our daughters can be whomever they want to be."

Following Guyton's performance, she was praised on social media by viewers and fellow country music artists. Kelsea Ballerini wrote, "Wow. @MickeyGuyton that is a performance that will make people listen, think, and change. Me included. You are a force."

Trisha Yearwood described the performance as "beautiful." Tenille Townes said Guyton's debut was "incredible." Many attached the hashtag "#MickeyMakesHistory" to their comments praising the singer.