Products containing CBD -- the buzzy cannabinoid used in everything from lotions to gumdrops -- will soon be showing up on the shelves of Walgreens stores across the country.
The retail chain announced Thursday it will begin offering certain products containing CBD, cannabidiol, in nearly 1,500 Walgreens stores in Oregon, Colorado, New Mexico, Kentucky, Tennessee, Vermont, South Carolina, Illinois and Indiana.
The CBD-related items offered in Walgreens stores will be topical creams, patches and sprays. The products will be "non-THC containing," according to the company.
THC, or tetrahydrocannabinol, is the chemical compound found in the Cannabis sativa plant that causes the “high” associated with marijuana. CBD does not.
"This product offering is in line with our efforts to provide a wider range of accessible health and wellbeing products and services to best meet the needs and preferences of our customers," Walgreens said in a statement.
Another retail giant, CVS, announced last week that it also will begin slowly rolling out CBD products in some of its stores.
“Anecdotally, we’ve heard from our customers that have used those products that, gee, it’s helped with pain relief for arthritis and other ailments,” CVS CEO Larry Merlo said in a CNBC interview. "We're going to walk slowly, but we think this is something customers are going to be looking for as part of the health offering."
With CBD becoming more easily available on the marketplace -- Soul Cycle is now selling it too -- and consumers have questions.
Here is what to know about CBD, from the health benefits to whether it's legal to use.
What is a Cannabinoid?
There are three types of cannabinoids. Endocannabinoids, which are produced naturally in the body; man-made cannabinoids, which can be really dangerous; and the most popular, cannabinoids such as THC and CBD, which come from the marijuana plant.
All three kinds of cannabinoids bind to cannabinoid receptors in the body. CB1 receptors, located primarily in the brain, are believed to control mood, memory, sleep, appetite and pain. CB2 receptors are located in parts of the body that produce blood cells, such as the spleen, and are believed to affect inflammation.
What is CBD?
CBD is short for cannabidiol, and it’s one chemical compound found in the Cannabis sativa plant — in both marijuana and hemp. CBD differs from THC (tetrahydrocannabinol) because it doesn’t cause the intoxicating, euphoric “high” associated with marijuana.
What are the health benefits?
Though there are claims of health benefits wherever you go, the science isn’t quite there yet — most of the research that has found benefits was done on animals. That’s because researching marijuana legally is difficult. Marijuana is a schedule I controlled substance, defined as having “no accepted medical use and a high potential for abuse.”
Still, there’s a lot of anecdotal evidence.
In June 2018, the FDA approved a CBD-containing seizure medication called Epidiolex, which can be used for the uncontrollable seizures caused by diseases such as Dravet Syndrome, a seizure disorder that can be uncontrollable with typical medications.
One of the most common uses of the drug, which is in a form called Dronabinol, is FDA-approved for chemo related nausea and vomiting. It is also used to help with appetite stimulation, especially in the cancer or AIDS population.
CBD is also widely used to treat pain and anxiety. Scientists are quick to say they are still unsure of the way this works, but they believe it may be due to CBD altering some brain pathways linked to these symptoms.
In skin care, CBD has been reported to treat itchiness, acne and allergic dermatitis — a skin reaction to allergies. While the mechanisms here are also unknown, scientists think it may be due to cannabinoid receptors in the skin which, when activated, work to reduce inflammation and arthritis.
As states move to legalize these compounds to the public, all of these claims will need to be studied.
How do people use CBD?
Many CBD products are sold as oils or balms, but they are also available in lotions, facial serums, lozenges or as part of cocktails. Although manufacturers claim there is an appropriate dose for the products they make, that is up for debate. The nutrition and supplement business, in general, is highly unregulated and this includes CBD products, even in states with legal marijuana.
What are the risks?
Both the benefits and risks of CBD lack substantiated research. As with any supplement, there is always a risk for unintended drug interaction. A small number of studies on animals indicate that CBD could potentially affect cell health and the breakdown of drugs in the liver. In humans, a study that investigated CBD’s effect on seizures noted side effects including diarrhea, vomiting, fatigue and increased sleepiness.
Why is it popular now?
In a word: marketing.
Similar to vitamin C and kale, CBD is undergoing a rise to fame just similar to the way that kale has been labeled a “superfood,” which is a non-medical buzzword. And with celebrities publicizing anecdotal benefits, there’s been easing tension surrounding CBD’s stigma.
But most importantly, as mentioned, it’s being marketed as a fix for various ailments.
Is it legal to use CBD?
Not Exactly. As mentioned, marijuana is still a schedule I substance, and that includes CBD.
The issue of legality comes down to how the CBD is obtained. The THC portions of the cannabis plant include the flowering tops (buds), the leaves and the resin of the plant. The remainder — the stalks and sterilized seeds — is where most CBD comes from. However, producers can also obtain it from the THC portions in which case it might yield a mixture of THC and CBD.
According to Katherine Pfaff, a spokesperson for the DEA, “If the product does cause THC to enter the human body and/or contains greater than 0.3 percent of THC, it is an illegal substance that may not be manufactured, sold or consumed in the United States. If, however, the product does not cause THC to enter the human body and contains less than 0.3 percent THC, it is a non-controlled substance that may lawfully be sold.”
The National Institutes of Health lists over 150 studies involving CBD as a treatment for various diseases. The World Health Organization concluded in a press release that CBD is not harmful. And in the sports world, the World Anti-Doping Agency removed it from its prohibited substances list.
To top this off, CBD is widely available online as well as in countless bars and coffee shops nationwide. This legal ambiguity undoubtedly confuses consumers, and it won’t change until further research trickles in.
The bottom line is there are countless claims regarding CBD’s ability to cure common ailments and there are also many places to buy CBD over the counter. But while there are many people willing to answer for CBD, the reality is there are still many questions that the industry itself needs to answer.
Dr. Sumir Shah, an emergency medicine physician in New York City, and former member of the ABC News Medical Unit, contributed to this report.